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Despite its promising anticancer properties, curcumin's clinical efficacy is significantly limited by its poor oral bioavailability, attributed to its low aqueous solubility, rapid metabolism, and systemic elimination ( 6.2 Combined effects of quercetin and exercise in CRC Although quercetin exhibits anti-inflammatory, antioxidant, and neuroprotective effects that may improve quality of life and reduce cancer-associated symptoms, its direct antitumor efficacy in CRC appears modest

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