Gene expression does not automatically equal clinical effect
Patients with severe cardiac, hepatic, or renal disease should also avoid testosterone injections, as exogenous androgens may exacerbate edema and other complications in these conditions
p53-pS15 is a major focal point in p53 activation to mediate p53-dependent transcription or growth arrest, Ser 15 phosphorylation triggers a sequence of additional sites phosphorylation in p53 (including Ser9, -20, -46 and Thr18) that contribute further to p53 activation 28
In the first test (the Ames test), they exposed bacteria to AOD9604 to see if it caused mutations
This result may have been driven by Erysipelatoclostridium and Lactobacillus , the only two microbial genera that significantly differed between the 5A-1MQ-treated and the vehicle-treated mice both switched from WD to LD