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As the main problem lies in the lack of endogenous insulin production, all T1DM subjects will have low portal insulin levels, even when treated with subcutaneous insulin, as this will only increase systemic insulin concentrations

10.1016/s0736-5748(03)00038-8 Summary Keywords neurotoxicity, neurodegeneration, disinfection byproducts, iodoacetic acid, neuroinflammation Citation Wang X, Rong C, Niu P, Leng W, Wang G, He Z, Qi X, Zhao D and Li J (2025) The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection

Additional oral supplementation with polypodium leucotomos extract (PLE) at 480 mg twice daily can be helpful (anecdotal evidence, unpublished)

Methods In this case-control study, we recruited 16 patients with T2DM (7 without and 9 with microvascular complications), and 8 age- and sex-matched non-diabetic controls

Vitamin injections are generally well-tolerated