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To determine the location of oxidative damage, confocal live-cell imaging was utilized to show contact between mitochondria and plasma membrane for an extended period of time in response to carbon starvation and LPS treatment

Ewert A, Leifheit-Nestler M, Hohenfellner K, Buscher A, Kemper MJ, Oh J, Billing H, Thumfart J, Stangl G, Baur AC, Foller M, Feger M, Weber LT, Acham-Roschitz B, Arbeiter K, Tonshoff B, Zivicnjak M, Haffner D (2020) Bone and mineral metabolism in children with nephropathic cystinosis compared with other CKD entities

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HUBERMAN: So whether or not you consider that a side effect or a benefit depends on, I guess, your baseline level of pigmentation and how much level of pigmentation you actually want

Another trigger for the induction of the MPTP in the context of APAP-induced liver injury is lysosomal iron, whose translocation to the mitochondria has been shown to occur in mouse hepatocytes treated with APAP, where it then induced opening of the MPTP75