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J Phys Chem B 110(12):58295833 Yu YJ, Watts RJ (2023) Developing therapeutic antibodies for brain diseases
These transcriptional effects of SREBP include (but are not limited to) increased expression of glucokinase (encoded by GCK), liver pyruvate kinase (encoded by PKLR), lipoprotein lipase (encoded by LPL), fatty acid synthase (encoded by FASN), and acetyl-CoA carboxylase 1 (encoded by ACACA), and decreased expression of glucose 6-phosphatase (encoded by the G6PC gene), fructose 1,6-bisphosphatase (encoded by FBP1), and mitochondrial phosphoenolpyruvate carboxykinase (encoded by PCK2)
Interestingly, duplications or triplications of the SNCA gene are also linked to PD and increased levels of wild-type -synuclein can accelerate Lewy body pathology [225]