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CLDN 2: Claudin 2

Anaphylaxis can impact multiple organs and, if left untreated, lead to coma, organ failure, and death

Periodontitis-associated salivary microbiota exacerbates colitis and anxiety in mice via gut dysbiosis and found altered metabolism of histidine in the gut and brain (Qian et al., 2023)

30,31 In addition, mitochondrial oxidative stress may also trigger the phosphorylation of glycogen synthase kinase-3 (GSK-3), which activates the mixed lineage kinase 3 (MLK3) protein

Glutathione binds to and neutralizes oxidative compounds such as carbon radicals, hydroperoxides, superoxide, nitric oxide, peroxynitrites, and lipid peroxides.* [3] Mitochondria are the energy-producers of each cell and depend on glutathione for protection.* When free radicals damage mitochondria, their activity becomes sluggish, and they can contribute to further mitochondrial oxidation