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Genetic engineering makes use of fundamental knowledge on the complex matter of folate biosynthesis and its regulation, part of which remains to be elucidated

For these reasons, a comprehensive understanding of the disease, as well as the search for new predictive/diagnostic/prognostic tools, is highly desirable

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This likely stemmed from the higher substrate availability in E-Sol5, which also resulted in increased steady-state levels of all glycolytic intermediates throughout the storage