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Important milestones in the GHK-Cu literature include the original 1973 identification of GHK as a plasma-derived cell proliferation factor, the recognition of the copper-binding role in the late 1970s, the wound healing and collagen research of the 1980s and 1990s, the establishment of GHK-Cu as a cosmetic ingredient in the 1990s and 2000s, and the transcriptomic expansion of the research literature in the 2000s and 2010s

PMID: 41754776

However, there are no well-controlled studies in pregnant women, so this medication is generally recommended during pregnancy only when clearly needed

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Online communities promoting these compounds together lack medical or scientific oversight, and anecdotal reports should not be treated as evidence of safety or efficacy