Furthermore, hm 5 C abundance appears to be clinically relevant
9,13 Thyroid stimulating hormone (TSH)
Elevation of cAMP in rat spinal cord neurons by rolipram, a PDE4 inhibitor, or dibutyryl-cAMP, is neuroprotective and is associated with the increase in proteasome function by enhancing 19S regulatory particle ATPase 6 (Rpt6), and 5 subunit of the central beta-rings of 20S proteasome activity and other components of the UPS including UBB and the E3 ligase CHIP, resulting in a decrease in aggregation of ubiquitinated protein in SCI (Myeku et al., 2012)
Meghan McGee-Lawrence has received a Notice of Grant Award from NIH that her NIA U01 grant ($2.36M) will be funded (award total: $2,365,732)
Low dose bexarotene treatment rescues dopamine neurons and restores behavioral function in models of Parkinsons disease