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In pre-clinical research, DSIP is often used to examine neurotransmitter interaction, sleep-cycle signaling markers, and stress-response modulation pathways

The benefits of lipophilic analog delivery into the brain might countervail the change of drug pharmacokinetic parameters [171]

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It is believed that increased immune activation induced by CTLA-4 blockade may trigger a compensatory response that leads to an increased IDO expression, further contributing to immune exhaustion (234)

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