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BAs indeed represent signaling molecules regulating different metabolic pathways involving the nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), vitamin D receptor (VDR), Gprotein coupled receptors (TGR5 or GPBAR1), cJun Nterminal kinase (JNK), and extracellular signalregulated kinase (ERK)

again, this is relevant mainly for oral supplementation, but it suggests caution in patients taking separate high-dose biotin supplements

psychiatry 64 (7), 589598

Herrmann C

In this trial, it was shown that ALA might have the potential to prevent the neuropathic impairments progression with regular long-term administration