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10.1007/s00125-017-4326-z 4 BacosK.PerfilyevA.KaragiannopoulosA.CowanE.OforiJ

Ethics declarations Competing interests B.G

J.HarjutsaloV.ForsblomC.GroopP.-H.LehtoM

It crosses the cell membrane and translocates to the nucleus under metabolic stress, where it regulates nuclear gene expression tied to glucose metabolism and oxidative capacity

In aging research, the compound provides a unique approach to investigating theories of metabolic decline, as NNMT expression increases with age in many tissues, potentially contributing to the NAD+ decline associated with aging processes