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Genome Res 23(9):1446-61, 2013

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The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis

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GSH as cysteine storage and the -glutamyl cycle Storage of cysteine is one of the most important functions of GSH because cysteine is extremely unstable extracellularly and rapidly auto-oxidizes to cystine, in a process that produces potentially toxic oxygen free radicals (Meister, 1988)