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ROCK activation can suppress eNOS activity and reduce NO-mediated vasodilation, while simultaneously favoring smooth muscle contraction (111, 120)

Opioids are sought for nonmedical use and are subject to diversion from legitimate prescribed use

doi: 10.1161/01.HYP.27.3.643

There is currently no established pharmacological mechanism by which tirzepatide would directly cause sleep disruption, though research in this specific area is limited

Biol Psychiatry 78:702710 Pearce R, Owen A, Daniel S, Jenner P, Marsden C (1997) Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease