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Selenium is included for its ability to bind heavy metals, reducing their toxicity and aiding in their safe removal and Trimethylglycine (TMG) supports liver function and the methylation process, an essential component of detoxification

[Article] [PubMed]52

In summary, CKD-related gut microbial dysbiosis accelerates renal function decline by sustaining a vicious gut-kidney axis cycle that amplifies oxidative stress, inflammation, and metabolic toxicity ( Figure 3 )