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Innate immunity and neurodegeneration
Although the secretion of pro-BDNF by central nervous system (CNS) neurons has been debated 28 , recent studies have explored the relevance of BDNF isoforms as biomarkers in non-invasive body fluids, using validated immunoassays 29
Beyond POTS, autonomic dysfunction in long COVID can present as: Dysregulated sweating Impaired gastrointestinal muscle contractions, causing constipation, pain, nausea, or weight loss Temperature dysregulation An exaggerated fight-or-flight response The vagus nerve within this systemthe primary parasympathetic nerve connecting the brain to the gut, heart, and lungsappears to be particularly vulnerable to COVID-19-related damage, with implications for heart rate variability, gut function, and the inflammatory regulatory role the vagus nerve normally performs
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