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In: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging (2015)

While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimers disease

And to do that all of the other delivery methods that could be used need to be thoroughly evaluated, not only as to their effectiveness in correcting the patients B12 Deficiency, but also in how the patient responds to particular delivery methods

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