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As we get older, we make less stomach acid, making it harder to absorb B12

ADC: Supervision, Writing original draft, Writing review & editing, Conceptualization

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Tirzepatide's dual mechanism of action, activating both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the GLP-1 receptor, produces superior metabolic effects compared to GLP-1-only approaches demonstrated in head-to-head clinical data and confirmed commercially by its rapid market penetration

508,509,510,511 Additionally, GLP-1 mitigates liver inflammation and fibrosis by inhibiting the NF-B pathway, reducing the release of pro-inflammatory cytokines such as TNF- and IL-6, and thus suppressing inflammatory pathways