Recombinant Human IL-23 (C-6His) SPMN10-0.75 Sotorasib irreversibly inhibits KRAS G12C

Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state

The recent identification of new substrates of polyglutamylation indicates that this post-translational modification could be a potential regulator of diverse cellular processes and be involved in cell cycle and cell proliferation

5'…GCG↓C…3'

3'…CAR↑YTG…5'

and the emission maximum shifts to 650nm (red)

Recombinant Human IL-23 (C-6His) SPMN10-0.75 Sotorasib irreversibly inhibits KRAS G12CRecombinant Human Interleukin 23 is produced by our Mammalian expression system and the target gene encoding Ile23 Ser328&Arg20 Pro189 is expressed with a 6His tag at the C terminus.