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2), peak width (Fig

The predictive algorithm developed using the abovementioned nine significant metabolites was as follows: Logit (P) = ln (P/ (1-P)) = 61.645 + 2.991 Leucine + 2.08 Serine + 1.735 Alanine + 0.394 Glucose + 6.134 Methionine 0.313 Isoleucine 0.072 Valine + 0.256 Glycylproline + 0.346 Glutamine

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Haematologica 97 , 18261835 (2012)

Patients may present with: Recurrent nosebleeds Heavy menstrual bleeding Easy bruising Gastrointestinal bleeding Surgical bleeding complications Iron deficiency anaemia Chronic fatigue The complexity of VWD contributes to these diagnostic challenges