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Previous studies have demonstrated that elevated uric acid levels decrease NO production in human umbilical vein ECs (HUVECs) (31-34)

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As previously reported, women with a history of PE are at an increased risk of long-term coronary heart disease, heart failure, stroke, and cardiovascular disease-related death later in life 3 , and their offspring are also at an elevated risk of hypertension and cardiovascular disease 4

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Placing the sulfur atom in cysteine with the two other amino acidsglycine and glutamateis the key