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112 More recently, it was suggested that methotrexate causes ferroptosis through activation of autophagy, leading to increased degradation of ferritin and liberation of ferrous iron (ferritinophagy), which promotes LPO and liver injury

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Int J Vitam Nutr Res (2007) 77(5):33640.10.1024/0300-9831.77.5.336 84 AmbrosiGCerriSBlandiniF

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doi: 10.1038/ncomms10690 11 SharmaSLeeDLiBQuinlanMTakahashiFMaheswaranSet al

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However, several factors, including age, genetics, and lifestyle, can influence our ability to produce sufficient glutathione

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