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(2) the specific CI inhibitor IACS-010759 was recently reported to promote neurotoxicity, making this an unattractive agent for combination therapy in CRC given the neurotoxicity long-recognized with oxaliplatin treatment 51

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Periodic blood tests (e.g., serum B12 levels, complete blood counts) may be recommended

However, a functional role of mitochondrial disease in ASD phenotype has been proposed by some researchers [74]