glutathione reductase inhibitor Ectopic suicide inhibition of thioredoxin Structure of glutathione reductase homodimer.

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eNOS uncoupling is caused by deficiency or oxidation of tetrahydrobiopterin, an important cofactor for eNOS action, leading to increased generation of superoxide and decreased NO bioavailability (155)

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doi: 10.1007/s00018-022-04353-8 462 YamakiH.YamaguchiM.TsuruoT.YamaguchiH