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In parallel to the finding of Wang et al., Gialluisi et al

MGF and Cardiac Preservation Research Systemic delivery of the MGF E-domain peptide at the time of myocardial infarction in mice resulted in significant preservation of cardiac contractility at 2 weeks post-MI, with an inhibition of pathological hypertrophy and significantly fewer apoptotic nuclei in the viable myocardium of E-peptide-treated mice compared to untreated controls establishing the E-domain as the biologically active region responsible for cardioprotective effects

Combined with other pyroptotic genes, GPX4 can be used to build a prognostic model for diseases including malignancies, requiring further clinical validation [121,122]

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