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Investigators have developed temperature-responsive nano gels that could release the drugs loaded on them at elevated temperatures found in inflamed or diseased tissues

[DOI] [PMC free article] [PubMed] [Google Scholar] 344.Marra G., Cotroneo P., Pitocco D., Manto A., Di Leo M.A.S., Ruotolo V., Caputo S., Giardina B., Ghirlanda G., Santini S.A

Its primary mechanisms include promoting angiogenesis (new blood vessel formation) through VEGF upregulation, modulating the nitric oxide system in a context-dependent manner, activating the FAK-paxillin pathway to drive cell migration and tissue rebuilding, and regulating multiple growth factors (PDGF, TGF-beta, FGF) involved in organized tissue repair

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