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Recently, neurofilament light chain has been proposed as a useful marker for AD as evidenced in Down syndrome patients prone to Alzheimers disease [47]

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10.3109/13625187.2011.614028 116 SongH.LuD.NavaratnamK.ShiG

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Mechanistically, Rhbdd3 directly binds to the Lys27 (K27)-linked polyubiquitin chain on Lys302 of the regulatory factor NEMO (IKK) via its ubiquitin-binding (UBA) domain in the endosome