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In Huntingtons disease (HD), GABAergic medium spiny projection neurons (MSNs) in the striatum are primarily affected while in Parkinsons disease (PD) the dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) undergo degeneration

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Thus, an improved understanding of the regulation of UA and its neuroprotective action in the human brain will shed further light on neurodegenerative processes and potentially identify novel targets for pharmacotherapeutic intervention

These condensates markedly increase local protein concentrations, facilitating multivalent interactions and sheet transitions that drive fibril formation [179]

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