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These changes include higher levels of Enterococcus and Streptococcus species and increased Enterobacteriaceae , while beneficial Bifidobacteria and anti-inflammatory Firmicutes are decreased [21,22,23, 27]

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was supported by the National Key R&D Program of China (2023YFC2306300), the National Natural Science Foundation of China (32170099), the Tsinghua University Dushi Program (20221080020 and 20231080040) and the TsinghuaPeking Center for Life Sciences