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(2015, European Neuropsychopharmacology ) investigated neural and cognitive processing changes following ARA-290 administration in human volunteers, examining its CNS modulatory properties Metabolic and Tissue Repair Research: Type 2 diabetes metabolic control Phase 2 study (Brines M et al., 2014) confirmed improvement in HbA1c and lipid profiles, with effects persisting throughout a 56-day observation period Pancreatic islet protection pre-clinical research has examined ARA-290 for cytoprotection of pancreatic islet cells via EPO/IRR anti-apoptotic signalling, relevant to both T1DM and T2DM research Wound healing and burn models pre-clinical studies confirmed ARA-290 promotes vascular repair and improved relative vascular area (RVA) in burn wound models via IRR-mediated angiogenic signalling Acute kidney injury models confirmed beneficial effects in AKI pre-clinical models via IRR anti-apoptotic and anti-inflammatory pathways Pulmonary and sarcoidosis models beyond neuropathy, ARA-290 has been studied in sarcoidosis systemic inflammation models, examining IRRs role in multi-system inflammatory disease modulation What Do Studies Say About ARA-290 Peptide