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9 Expert commentary NPs platforms have the ability to revolutionize the delivery of therapeutics to the CNS due to their tuneable size, shape, surface charge, and ability to conjugate any number of ligands (205)

doi: 10.3389/fimmu.2017.01463 298 Fritz-FrenchCTyorW

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We then investigated the dopaminergic system at pre-symptomatic and symptomatic stages

This NAD+ elevation activates sirtuins (particularly SIRT1), enhances mitochondrial function, and preserves methylation capacity by reducing S-adenosylmethionine (SAM) consumption