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Acknowledgements We acknowledge the AAV Core Facility of Academia Sinica for generating recombinant AAV (Grant AS-CFII112-204)

The injection schedule is usually adjusted according to individual needs

IM up to 3/week provides less frequent, moderate dosing

Elevated TSH levels have been independently associated with retinal arteriolar narrowing and reduced arteriovenous ratios, suggesting their role in microvascular pathology [155]

This targeted approach is why it's often highlighted for its favorable safety profile and is considered a valuable tool in therapeutic applications aimed at optimizing growth hormone levels