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The active fraction turned out to be a tripeptide glycine, histidine, lysine bound to a copper ion.1 That observation kicked off five decades of research

Following the remodelling phase, a higher proportion of synthesised type I collagen, a corresponding decrease in cellularity, glycosaminoglycan content and type III collagen (Sharma and Maffulli 2005) can be observed

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However, no studies have investigated topical VEGF or biomimetic peptides alone