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This is a mechanism with enormous relevance to anyone already taking a GLP-1 receptor agonist, and it sets up the overlap discussion that matters most for this guide

Non-selective COX inhibitors, such as ibuprofen and indomethacin, can induce gastric ulcers and hypertension by suppressing COX-1 mediated prostaglandin synthesis

Glutathione metabolism is impaired when not protected, and systemic effect remains low

So if you're having trouble sleeping or just don't feel refreshed when you wake up to start your day, be sure to speak with your health care provider about steps you can take to improve your sleep

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