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Description

Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids

PMID: 49 WuJMinikesAMGaoMBianHLiYStockwellBRet al

IGF-1 LR3 is modified at two positions (N-terminal 13-amino-acid extension and Arg3 substitution) to substantially reduce IGFBP-3 binding, extending preclinical activity duration well beyond the roughly 10 to 12 minutes seen with unbound native IGF-1

The evidence for this mechanism in humans is biologically plausible but not yet conclusively established in high-quality clinical trials see the evidence table