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Most patients begin feeling relief within 3060 minutes as hydration and magnesium help relax vascular constriction and ease pain

Pentylenetetrazol (PTZ), a -aminobutyric acid (GABA)ergic receptor antagonist, has a stimulant epileptogenic property and is commonly used as a convulsing drug in experimental studies

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Studies confirm that ion release (Ca 2+ , F , PO 4 ) at acidic pH (4.5-5.5) is markedly higher than at neutral pH (6.5), a trend sustained even after recharging (Venkataiah et al., 2025)

Voxel-based morphometry reveals increased gray matter density in Brocas area in male symphony orchestra musicians