Mitochondrial dysfunction can drive senescence via reactive oxygen species (ROS) accumulation [68, 69], and Tat ( morphine) perturbs mitochondrial function, increasing ROS, protein oxidation, and cytokine release in microglia [60, 70]
N-acetylcysteine is currently used to loosen thick mucus in people with cystic fibrosis or chronic obstructive pulmonary disease (COPD) (10)
J Gen Virol 99(12):16581670 Kerur N et al (2013) TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy
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