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Combination of EPA with carotenoids and polyphenol synergistically attenuated the transformation of microglia to M1 phenotype via inhibition of NF-B

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Patients who are deficient in G6PD, which is the rate-limiting enzyme in PP pathway, have a lagging in NADPH production, hindering those cells vulnerable to VC-induced oxidative stress, subsequently leading to erythrocytes death, thereby causing anemia (39)