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Associations of CYP2C9 and CYP2C19 pharmacogenetic variation with phenytoin-induced cutaneous adverse drug reactions

Follow-up work has demonstrated that MC signaling within the NAc contributes to alcohol consumption by modulating the non-homeostatic aspects (palatability) of intake (Lerma-Cabrera et al., 2013b), which bring to light the key role of MCs in limbic regions implicated in the hedonic response to alcohol

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This means that it does not have a natural model of action and may potentially cause unwanted side effects during long-term administration