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UPR can avoid the ERS-caused damage by reducing the accumulation of unfolded proteins and improving the correct folding of proteins, and restoring normal physiological functions of cells

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HepG2 cells were treated with 5 mol/ml (Figure 1A) and 10 mol/ml (Figure 1B) of ASA for 48 h and GSH levels in the mitochondria and post mitochondrial supernatant (PMS) were measured by enzymatic method as described in the Materials and Methods