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To meet the diagnostic criteria for mEDS, a person must meet: Major criterion 1 AND at least one other major criterion OR Major criterion 1 AND at least three minor criteria Major Criteria Congenital muscle hypotonia and/or muscle atrophy that improves with age Proximal joint contractures (knee, hip, and elbow) Hypermobility of distal joints Minor Criteria Soft, doughy skin Atrophic scarring Motor developmental delay Myopathy on muscle biopsy Periodontal EDS (pEDS) If a person meets the diagnostic criteria for pEDS, genetic testing should be done to confirm the diagnosis

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Acute toxicity test of plant extract and administration The LD of the plant extract was determined using Lorkes method 30

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