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1 Introduction Diabetes mellitus (DM) is a major global health problem, affecting over 537 million adults aged 2079 years worldwide (Sun et al., 2022)

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Clears damaged ECM Promotes proper collagen remodeling Enhances long-term tissue strength GHK-Cu regulates both MMPs and their inhibitors, enabling balanced matrix remodeling and improved skin regeneration. Pickart et al., Biomed Research International 4

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PST findings did not predict at least 50% improvement with pentosan polysulfate (PPS) 81 or with combined heparinoid and tricyclic antidepressant treatment