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10.4161/derm.2.2.13509 Dermatoendocrinology 137 LinkE.ParishS.ArmitageJ.BowmanL.HeathS.MatsudaF.et al (2008)

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[39] demonstrated that the IGF-1R-induced activation of STAT3 was dependent on the phosphorylation of JAK1 (Fig

Dysregulated iron metabolism, including increased expression of transferrin receptors and ferritin degradation, leads to iron accumulation, contributing to ferroptosis ( 2+ acts as a cofactor for LOXs and prolyl hydroxylase, which are critical enzymes involved in lipid peroxidation and oxygen homeostasis ( During the first trimester, hepcidin levels increase, while in the second trimester, hepcidin levels decrease despite stable serum iron levels