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Why increased norepinephrine in conjunction with normal or low epinephrine is a worse situation than just high epinephrine, due to the lack of counter balance for inflammation and an upregulated innate immunity

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Thus, it is well-established that increased ROS and MDA levels, or reduced levels of antioxidants like SOD, GPx, and catalase, signify mitochondrial dysfunction and oxidative stress, which is also associated with cognitive impairment