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Chronic hyperglycemia initiates a cascade of molecular eventsincluding the accumulation of advanced glycation end products (AGEs), activation of the polyol pathway, enhanced protein kinase C (PKC) signaling, and mitochondrial dysfunctionculminating in glomerular hyperfiltration, podocyte injury, and progressive glomerular and tubulointerstitial fibrosis
Springer, 39-51, 2013
But if you combine regular, moderate alcohol use with repeated daily doses of acetaminophen, it can make your liver more susceptible to a condition called acetaminophen toxicity
Annu Rev Immunol (2016) 34:33568
Both TNF- and heat shock proteins (released from damaged, stressed, or dead cells) upregulate NOX activities and ROS production in microglia [432,433], which have been suggested to play a key role in the pathogenesis of glaucoma [434]
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