One animal study (Valdecantos et al., ADA 2024) showed obese rats given both compounds at sub-maximal doses lost more weight than either compound alone
Of clinical significance is the short-chain dicarboxylic acid, oxalic acid (oxalate)
Finally, the sections were coverslipped using ProLong Gold Antifade Reagent (Thermo Fisher Scientific, Waltham, MA, USA)
204 Challenges and future directions toward clinical translation Although the gut microbiome shows immense potential as biomarkers for liver disease, its move toward large-scale clinical application still faces multiple challenges such as standardization, causality, and personalization
Statistical analysis All analyses were conducted using the RStudio version 1.4.17.17 software by the packages meta and metafor. We used the method suggested by the Cochrane handbook to calculate the sample size and event [19]