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The activation of serine biosynthesis pathway enhances NADPH generation in cancer cells

Due to cardiomyocytes requiring massive energy demands, they are rich in mitochondria standing out from the rest of the cell type [15, 16], which makes them very sensitive to oxidative stress damage

Indeed, our previous findings revealed that silencing CDCA7 , a gene overexpressed in lymphoid tumors, specifically inhibited cell growth in 3D gels, without inhibiting proliferation in 2D conditions, and reduced lymphoma growth in vivo and tumor cell migration and invasion [32, 37]

A familiar culprit This work builds on recent significant work from the Birsoy lab

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