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The 2013 paper by McCoy et al

The product has not been tested during breastfeeding, in pregnancy, in children younger than three years of age and during the administration of other products for topical use in the nasal cavities

Most researchers report no noticeable potency issues at the 5-week mark, but conservative protocols suggest using the vial within 4 weeks and discarding any remainder

Nevertheless, its effect on S-AKI remains unclear and requires further research