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Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective

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To directly assess whether MT1 or MT2 mediate melatonins effects in ILC2s, we treated cells with selective MT1 and MT2 agonists and antagonists

The researchers further illuminated that HMGB1 translocates from the nucleus to the cytoplasm and binds to cytoplasmic Toll-like receptor, resulting in the activation of p38 and subsequent phosphorylation of PGC-1, which upregulates mitochondrial biogenesis, finally promoting tumor survival and proliferation

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