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And (child of the 70s, teen of the 80s here) I am a rueful and belated adopter of sunscreen

Another miRNA shown to regulate Nrf2 is miR-34, able not only to target NFE2L2 but also downstream genes involved in cellular response to OS, such as microsomal glutathione S-transferase 1 ( Mgst1 ) and Sirtuin 1 ( Sirt1 ) genes in rat liver during aging [226]

Jin ES, Sherry AD, Malloy CR

characterized a mouse model of ALS with a mutant mtSOD1 gene with a Glycine to Alanine substitution (SOD1G93A) to clarify the etiology of the disease (Soares et al., 2023)

Healthy mitochondria are essential for neuronal health and function